The Effects of Feeding Behavior on Brain Plasticity in the Developing Brain

Claudia received her PhD in Integrative Molecular Medicine from the University of Zürich, Switzerland. Her graduate focused on the metabolic and neurogenic effects of the satiating hormone amylin in the rodent area postrema (AP). Specifically, she investigated the co-expression of all the components of the amylin receptors at the single cell level, in amylin-activated AP-neurons. Her work demonstrated that amylin has the potential to differentially regulate transcription. Furthermore, her work showed that amylin modulates genes involved in neurogenesis like-processes and that chronic amylin treatment significantly increased cell proliferation in the AP of adult rats.

Her current research in the Hayes lab is building upon her graduate work and extends towards understanding the neuroendocrine systems regulating energy balance (e.g; amylin and GLP-1 signaling) and how perturbations in these systems can affect the onset and the progression of obesity. She is particularly interested in examining the contribution that these neuroendocrine systems have in shaping brain plasticity (specifically the hindbrain) and feeding behavior during development throughout adulthood.