Novel Sites Of Action For Feeding Related Peptides

Identifying novel mechanisms and sites of action for the control of energy balance is one of main focuses of the Hayes lab. Previous work from the lab showed that GLP-1 receptors (GLP-1Rs) are expressed on astrocytes within the nucleus tractus solitarius (NTS), a feeding relevant nucleus, and contribute to energy balance control. Some of our recent work has shown that GLP-1R signaling in the lateral dorsal tegmental nucleus (LDTg), an understudied region in energy balance control, regulates energy balance control. We also identified the LDTg to be a novel site of action for the hormone amylin, which was traditionally believed to act in the solely in the area postrema.